Mark Twain thought that humor was based on pain (certainly a lot of HIS was) and he said there would be no need for laughter in Heaven. Or words to that effect.
For my own druthers, I'd say there'll be no addiction in Heaven. Not to booze, not to drugs like tobacco (or others), not to pain or rage, not to each other. Maybe that should be broad enough to include no compulsions, either.
Lennon's "Imagine" is full of what there'd be none of -- "nothing to kill or die for -- and no religion, too."