There's a lot of power to what LH says; the difficulty arises when the series of mind<=>body interactions stack up. You build up a mess o' undelivered unspoken communications, worries, upsets or whatever, and ignore them while they have the usual deleterious effect on the mind<==>brain boundary, with depressing side effects. Being thus depressed, you eel less and less like facing squarely what continues to be unhandled in LH's checklist above, which inturn solidifies the locked in stacks of unhandled despair. Eventually, the walls come down and you are swamped by the grim washes of deep depression.

There are ways out of these mazes using non-chemical means but they require a bootstrap operation calling for more energythan the individual usually has by that time. Hence the lassitude and inertia. Change requires free attention.

In the most extreme cases, it really sometimes seems that chemical intervention is needed to settle or subdue the chaos of a mind too long neglected long enough to start change happen. But I would never resort to it if anything less would serve, because it is itself an invasive and disruptive remedy. It subdues symptoms, buries them under a numbing layer of chemistry whoch dampens and quiets the nerves. The nerves aren't the source of the situiation at all!

This is kind of like turning down the volume on the phone handset because you don't like the noise and static on the lines which is caused by water in the junction boxes three miles away.

A