"you can get a buzz(from)one string bumping up against the wrap of another enroute to its own tuner."
Santa Cruz had to make a minor alteration to their headstocks on some models for that very reason. The fifth (A) string had a tendency to rub on the winding of the sixth (E) string. They now offset the tuner shafts on the second and fifth strings about 1/8 inch toward the center of the headstock to prevent such rubbing.