I wouldn't think learning to play it strung the other way would be that different from learning to play a new instrument, and people do that all the time. If you played along with a bunch of people with their instruments strung the other way the natural thing would be to experiment with playing their instruments.

I've always fancied having a go at a left hand strung mandolin, once I realised that GDAE backwards is EADG, the same as the bass strings on a standard tuning guitar, which would mean I could use all the guitar chords I know, and it'd be interesting to hear what they sounded like back to front. But I've never played with a mandolin player with a mandolin strung left handed.