One of my favorite guitar 'sounds'is a common one: playing in F when you drop into C. I also really like the sound in taking the E chord to D. Real lift there, even though it's lower.

Lately a friend and I are practicing flat picking up the neck- strangely enough, picking in E up there is no harder than picking E in first position. Maybe because in first position you are used to thinking that there are occasional open strings, while up the neck you know there ain't any?