Missouri was also a wake-up call to the Democrats. Although the vote was split almost 50-50, a look at the map shows that Obama carried only the cities of St. Louis, Kansas City and Jefferson City. The entire state outside of these cities was solidly for Clinton. Only 5 of 141 counties showed a majority for Obama. One may duplicate the results across the country.
Much of the Obama 'lead' was engineered in the caucus votes, which never attract 'middle' Americans because they appear to them as elite closed circles.

I have just about reached the point of putting my money on McCain, although I fear nothing innovative will come from his leadership.
Of course, a Democratic president in the White House can only accomplish so much in a divided Congress, which is a certainty.
A moderate advance in health care, legislation encouraging development of nuclear and other energy sources, possible legislation leading to a partial solution of immigration problems, and a gradual realization that the Middle East conflicts cannot be resolved by the American military or by thwarting legitimate Middle East aspirations or ignoring their complex demographics and cultures, are perhaps the best we can hope for.
'Change' will come slowly regardless of the outcome.