BS: A Cancer Breakthrough wow!

Subject: BS: A Cancer Breakthrough wow!
From: olddude
Date: 24 Jan 12 - 08:16 PM

On the Buffalo New York News, Roswell cancer institute, the one that took care of my missus just announced a vaccine that has just been approved for trial by the FDA. They take a sample of your T-Cells and encode the cancer signature on it and inject into the body. The T-cell now recognize the cancer and kill it. Beyond that the T-cells reproduce normally and remember that the cancer is an enemy and continue to kill any cancer it finds. So far it shows the ability to prevent any cancer from coming back ... Holy Cow this could be good. For some of you with reoccurring issues you may want to give them a call

Dan

Subject: RE: BS: A Cancer Breakthrough wow!
From: kendall
Date: 24 Jan 12 - 08:18 PM

Excellent! I wonder if the medical profession will allow it? Cancer research is a cash cow for them.

Subject: RE: BS: A Cancer Breakthrough wow!
From: gnu
Date: 24 Jan 12 - 08:29 PM

Well, as much as this is good news, been done in Halifax, NS years ago. Been a thread here on it. Fact is, even tho the Canuck government money funded the initial reasearch (with seals on Sable Island), the private companies got into the mix and it's all about money. The one they found was a ONE dose vaccine that irradicated cancers throughout the body.

Now, I don't wanna rain on any parade, but Kendall raises a very valid question. What will be done? Cure cancer or make money? Big companies like money and they don't give a whit about you and me.

Subject: RE: BS: A Cancer Breakthrough wow!
From: gnu
Date: 24 Jan 12 - 08:52 PM

Odd that I can't find that thread with a filter search???

Subject: RE: BS: A Cancer Breakthrough wow!
From: GUEST,olddude
Date: 24 Jan 12 - 09:44 PM

Roswell is a cancer research hospital, one of the best in the nation. If they announce it, I don't think anyone will be able to put a lid on this one. The buffalo news said it will be on the national news also. The research scientist doc was pretty pumped up. What they want to know now is will the T-Cells remember for good or will they go away after a while. Only clinical trials will really prove it. However, they interviewed a lady that was in late stages of reoccurring ovarian cancer. She was one of the first to test the procedure. She had a year at most. Eight years later she is still cancer free and completely healthy so I am pretty excited about this news. She said it was a miracle. The other patients that were in the beta program, all got better and remained that way. cool

Subject: RE: BS: A Cancer Breakthrough wow!
From: LilyFestre
Date: 24 Jan 12 - 09:50 PM

OldDude....

    The last bit of your post made me cry tears of happiness. Thank you for sharing not only the news of the T-cells but also of the success they have had with ovarian cancer....the most deadly of the gynecological cancers.

XOXOOXOXOX

Michelle (Ovarian cancer survivor)

Subject: RE: BS: A Cancer Breakthrough wow!
From: maeve
Date: 24 Jan 12 - 10:07 PM

This thread, gnu? BS: Cancer - New Therapy
I hope these and other important therapies will not be railroaded off by commercial interests. "Cure"...It sounds wonderful.

Subject: RE: BS: A Cancer Breakthrough wow!
From: maeve
Date: 24 Jan 12 - 10:46 PM

Also of interest: http://www.tecca.com/news/2011/12/08/angela-zhang-cancer-siemens/

Subject: RE: BS: A Cancer Breakthrough wow!
From: ChanteyLass
Date: 25 Jan 12 - 12:22 AM

This is good news. I am sure the vaccine will be very expensive but hopefully less expensive for patients than treatment for cancer. I hope those who make their livings doing cancer research can turn their efforts toward other medical research. As for the profiteers, they will always be around.

Subject: RE: BS: A Cancer Breakthrough wow!
From: GUEST,Ian Mather sans cookie
Date: 25 Jan 12 - 02:09 AM

Oh dear. Kendall reckons cancer research is too much of a cash cow to let any cure happen.

That is the sort of irresponsible remark that cheapens these debates and precludes serious input.

Cancer is a group term and there are many inhibitors that stave off cell reproduction for many types of what collectively call cancers.

Big companies do want their research money back in a short time with profits, and one day, though not just yet, the silver bullet might be found. NICE are already making tentative trial plans and so if there is any reversing effect, UK patients might see a future licence too. But I feel we are still no nearer to prevention, just, as in healthy lifestyle, a step nearer to possibly slowing incidence.

And if this drug can do that for some types of oncological growths, then it will be a good thing. But I doubt cancer research labs are being redesigned into office blocks just yet.

Subject: RE: BS: A Cancer Breakthrough wow!
From: maeve
Date: 25 Jan 12 - 07:30 AM

Kendall has sound reasons to speak in that manner, Ian. I expect he'd be delighted to have the Theory of Commercial Interest Overcoming Healing Interest proven false.

Subject: RE: BS: A Cancer Breakthrough wow!
From: GUEST,Ian Mather sans cookie
Date: 25 Jan 12 - 08:33 AM

I am as cynical as the next person when it comes to commercial aspects of the pharmaceutical industry.

He didn't say that, he said the medical profession, and for that he is not only wrong but ignorant to boot. Hence an interesting thread loses credibility if such ill informed comments become part of the debate.

I am being a bit strong in my condemnation, but emotive subjects that include people who are genuinely seeking answers to life's lottery can do without it. There is no miracle cure out there, and if there was, I doubt Mudcat is where most of us will hear about it first. This breakthrough is an inhibitor that is presently being tested for contraindications. The effect it may eventually have on people's lives may be wonderful, but add it to others already out there such as Herceptin. I look forward to the day when oncology doctors can improve sufferers' lives, and in the far future, when we understand cancers more, that vaccine type drugs may slow the incidence.

It isn't polio, it isn't smallpox. It s our bodies doing what they sometimes do. This may be an important weapon in the arsenal, but it isn't a declaration of peace.

Subject: RE: BS: A Cancer Breakthrough wow!
From: maeve
Date: 25 Jan 12 - 08:38 AM

"I am being a bit strong in my condemnation," Yep.

"I look forward to the day when oncology doctors can improve sufferers' lives, and in the far future, when we understand cancers more, that vaccine type drugs may slow the incidence." Also yep.

Subject: RE: BS: A Cancer Breakthrough wow!
From: Arthur_itus
Date: 25 Jan 12 - 09:08 AM

As I am going through my second time of bladder cancer, this is of great interest to me. Seemingly very little side effects as well.

However, I will probably be 6 foot under before we see it appear in the UK.

Subject: RE: BS: A Cancer Breakthrough wow!
From: Jeri
Date: 25 Jan 12 - 09:24 AM

I agree with Ian. "I am being a bit strong in my condemnation, but emotive subjects that include people who are genuinely seeking answers to life's lottery can do without it."

I the pharmaceutical industry may find some benefit in being persistently unsuccessful, but most medical professional want their patients to get better. I think Kendall likely thinks so too and was just having a bit of a rant.

I believe there have been tests of cancer vaccines before, with varying degrees of success. I hope this one is effective.

Subject: RE: BS: A Cancer Breakthrough wow!
From: Rapparee
Date: 25 Jan 12 - 09:35 AM

My wife has had cancer twice. I'd be very interested in a vaccine, as she would be.

But there really is too much money to be made from cancer; besides, some will probably always be with us. And radiation, even sunlight, could mutate the stem cells.

Let's wait for more research.

Subject: RE: BS: A Cancer Breakthrough wow!
From: Bert
Date: 25 Jan 12 - 09:49 AM

If this was tested eight years ago then it seems that Kendall has a valid point; see posting 24 Jan 12 - 09:44 PM above.

How many people have died of cancer in the past eight years?

Subject: RE: BS: A Cancer Breakthrough wow!
From: GUEST,olddude
Date: 25 Jan 12 - 10:32 AM

The FDA moves in very slow ways. I think it took a real push publicly by Roswell to get it going. I think now the genie is out of the bottle it cannot be swashed so easy. The Captain had every right to be concern and so do others here. I am optimistic that maybe this will go off now internationally, Roswell is putting in millions in lab equipment to reproduce so I am thankful ... for those now suffering, I would have my doctor call them and get into the trial ya got nothing to lose I think which is why I started this thread. My missus so far is fine but if it returns I know what we will do.

Subject: RE: BS: A Cancer Breakthrough wow!
From: GUEST,olddude
Date: 25 Jan 12 - 10:40 AM

the difference in this vaccine is the encoding. My understanding is others tried to stimulate the t-cells however, unless the t-cells know that the specific cancer is an enemy, there is limited success. Roswell is making the T-cells know and remember that the cancer must be eliminated through encoding the cancer signature into the t-cell

Subject: RE: BS: A Cancer Breakthrough wow!
From: GUEST,olddude
Date: 25 Jan 12 - 10:43 AM

roswell vaccine

Subject: RE: BS: A Cancer Breakthrough wow!
From: bobad
Date: 25 Jan 12 - 10:52 AM

This is not a vaccine, as in what is commonly understood, in the preventative sense. It is rather a treatment for existing cancers.

It involves removing some peripheral blood from the cancer patient, selecting specific cells out, growing these cells in vitro while exposing them to antigens from the patient's own cancer then reinjecting them back into the patient. These now primed presenter cells, known as dendritic cells, activate another cell, called a cytotoxic T-cell, which will be programmed to recognize and kill the cancer cells.

Subject: RE: BS: A Cancer Breakthrough wow!
From: Jeri
Date: 25 Jan 12 - 10:53 AM

Information on some other cancer vaccine trials.

What if your loved one gets the vaccine that you think is supposedly great because the testing process is accelerated, and then the vaccine is found to be nowhere near as effective as the current treatment and your loved one dies.

Sometimes, the subjects in trials are accepted because nothing else has worked and they're expected to die. The reason is that the treatment being tested may not work or may actually do some unforeseen harm. The chance of finding an experimental treatment that proves to be the 'magic bullet' is probably not very likely.

Subject: RE: BS: A Cancer Breakthrough wow!
From: GUEST,olddude
Date: 25 Jan 12 - 10:58 AM

From WBEN buffalo

Dr. Odunsi, who developed the NY-ESO-1 vaccine, led previous trials evaluating its effectiveness in treating ovarian cancer. Christine Sable of Lancaster, Pennsylvania, enrolled on one of those studies in February of 2004, after undergoing surgery and chemotherapy for advanced-stage ovarian cancer. Although she faced a 75-80% chance that the cancer would return, her immune system responded strongly to the vaccine, and she has remained cancer-free in the seven years since then, with no side effects.

Subject: RE: BS: A Cancer Breakthrough wow!
From: bobad
Date: 25 Jan 12 - 11:02 AM

The process of making dendritic-cell vaccine is well illustrated in this PDF document.

Subject: RE: BS: A Cancer Breakthrough wow!
From: GUEST,olddude
Date: 25 Jan 12 - 11:09 AM

From Roswell:

Dendritic cells are the gatekeepers of the human immune system, defending against invaders like bacteria, viruses and cancer. The vaccine to be produced at RPCI will be the first to incorporate a particular form of NY-ESO-1, antiDEC205-NY-ESO-1. "Armed with this specialized protein, the treated cells are then given back to the patient as a vaccine designed to recruit an army of killer immune cells that seek out and destroy cancer," explains Kunle Odunsi, MD, PhD, Director of RPCI's Center for Immunotherapy (CFI) and the study's Principal Investigator.

The new study is also unique in that it's the first to test a dendritic vaccine given in combination with rapamycin, a compound used to prevent rejection of solid-organ transplant. The study just launched will capitalize on a striking recent scientific discovery by Protul Shrikant, PhD, of the Department of Immunology at RPCI, who found that in low doses, rapamycin confers a previously unknown benefit — it prevents the immune system from using up its cancer-killing T-cells in one quick burst. "We have shown for the first time that rapamycin has the capacity to produce immune cells that have memory attributes," explains Dr. Odunsi, who is also Chair of RPCI's Department of Gynecologic Oncology. "The immune cells are trained to live longer and to always remember that cancer cells are bad and should be attacked and killed."

The ability to stretch out the attack for a long-term, durable response suggests that the vaccine may be effective in preventing disease recurrence. The new NY-ESO-1 dendritic cell vaccine is expected to show great promise in patients with bladder, brain, breast, esophageal, gastrointestinal, hepatocellular, kidney, lung, melanoma, ovarian, prostate, sarcoma and uterine tumors.

The NY-ESO-1 vaccine, tailor-made for each patient, will be produced in RPCI's Therapeutic Cell Production Facility (TCPF) under the direction of Yeong "Christopher" Choi, PhD, who notes: "We believe that our facility's custom-made barrier isolator, the unit in which the vaccines are manufactured, is the first of its kind." The barrier isolator — an Xvivo System processing chamber designed to RPCI's specifications by BioSpherix, Ltd., Lacona, NY — maintains strict control of the unit's temperature and atmospheric gases, critical for optimal production of dendritic cell vaccines.

"Those conditions, and the sterile vaccine-manufacturing environment, are rigidly maintained throughout the entire process," says Dr. Choi. "The Xvivo — which at about 70 square feet is basically a clean room in a box — acts as a physical barrier that protects the cell-therapy product from outside contaminants, resulting in a safer, more predictable manufacturing process."

Subject: RE: BS: A Cancer Breakthrough wow!
From: maeve
Date: 25 Jan 12 - 11:13 AM

Fascinating reading. Thanks, olddude and bobad.

Subject: RE: BS: A Cancer Breakthrough wow!
From: bobad
Date: 09 Feb 12 - 04:27 PM

Doctors looking in the wrong place for ovarian cancer: study
Thursday, February 09, 2012 3:12 PM
   
MONTREAL - Researchers at the McGill University Health Centre (MUHC) in Monteral have made a life-saving discovery that will help earlier detection of ovarian cancer.

Dr. Lucy Gilbert, MUHC Director of Gynecological Oncology, led the team of researchers conducting the ground-breaking DOvE (Diagnosing Ovarian Cancer Early) study.

She explained that for many years, doctors have simply been looking in the wrong place for the source of ovarian cancer.

"The most startling finding is that the deadliest type of ovarian cancer, which accounts for 90 per cent of deaths, often starts in the fallopian tubes, not in the ovaries," she said.

Armed with this knowledge, the cancer can now be detected much earlier - when there is a better chance of successful treatment.

The study, which involved screening 1450 women aged 50 years or more, also revealed another startling issue.

The team discovered that those who showed mild symptoms of the disease were 10 times more likely to have ovarian cancer than women with no symptoms.

Mild symptoms include:
• Bloating
• The need to urinate frequently
• Abdominal or pelvic pain
• Difficulty eating, or feeling full quickly

"Don't let your doctor tell you it's menopause," Dr. Gilbert warned. "Get screened."

And the ability to get screened will now be much easier.

The MUHC announced that it will be setting up 12 satellite clinics dedicated to screening ovarian cancer in Montreal.

Full study (pdf)

Subject: RE: BS: A Cancer Breakthrough wow!
From: gnu
Date: 09 Feb 12 - 04:50 PM

Good news! Thanks, bobad.

Subject: RE: BS: A Cancer Breakthrough wow!
From: maeve
Date: 09 Feb 12 - 05:21 PM

That is beyond wonderful news, bobad. My cousin just died from this nightmare. I hope many women will benefit from this new information.

Subject: RE: BS: A Cancer Breakthrough wow!
From: Ed T
Date: 09 Feb 12 - 06:31 PM

This started from grey seal birth control research on Sable Island, stimulated by the government of Canada. Something good seems to have come from it, as those seals seem to be multiplying like guppies:)


First patient vacinated

Subject: RE: BS: A Cancer Breakthrough wow!
From: gnu
Date: 09 Feb 12 - 06:39 PM

Here's the first thread. Been more.

Great news, if the big companies don`t screw us over.

Subject: RE: BS: A Cancer Breakthrough wow!
From: gnu
Date: 09 Feb 12 - 06:43 PM

Ed T... what upset me at first was the fact thet the Canuck government funded to research wich led to COMPLETE erradication of cancers throught the bodies but that "private" companies had to be brought in to develope and market it. Money... always money.

Subject: RE: BS: A Cancer Breakthrough wow!
From: Beer
Date: 09 Feb 12 - 06:55 PM

Just watched that news story this evening Bobad on CTV.
adrien

Subject: RE: BS: A Cancer Breakthrough wow!
From: LilyFestre
Date: 09 Feb 12 - 07:18 PM

Regarding ovarian cancer...it is great news that they have found a place of origin, however it is not especially new news.

Still, a reminder to women and to the men who love them...those early symptoms are keys to survival.

Now if they would just come up with an accurate diagnostic test....it is because of this lack of a diagnostic that so many women don't know they have ovarian until the later stages which is often too late.

Ovarian cancer is the deadliest of the gynecological cancers killing 3 out of 4 women. There has been very little forward movement in research in the last either 10 or 20 years (I forget).

Michelle, Ovarian & Uterine Cancer Survivor

Subject: RE: BS: A Cancer Breakthrough wow!
From: Sandy Mc Lean
Date: 10 Feb 12 - 01:13 AM

While I should be elated somehow I am sadened at how greed can trump legacy! I really hope that history will prove me wrong!

Subject: RE: BS: A Cancer Breakthrough wow!
From: gnu
Date: 10 Feb 12 - 12:55 PM

Well said, Michelle.

Subject: RE: BS: A Cancer Breakthrough wow!
From: Donuel
Date: 10 Feb 12 - 03:44 PM

Having the correct address is a very good thing.