Depends on your definition of serious disagreements.
There have been in fact several times when hotheads in the government or outside--on either side-- have pushed for war between the US and UK. Not including the Revolution and War of 1812. More times when there has been considerable suspicion of the other side. And I'm somewhat surprised Kevin that you say that outside pub quizzes few in the UK would recognize the War of 1812.
The "special relationhip" is a recent phenonenon. And even that "marriage" has not been without its squabbles.
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sj