Subject: RE: BS: Curmudgeon: One Thing After Another
From:
Stilly River Sage
Date: 13 Dec 09 - 08:07 PM
I went to the database at work. These are 2 abstracts from articles in the university library medical database.
I'm sending these along because they may give you some useful keywords for a further search. The second one may be more useful.
Let me know if you want me to look further or send more information. I am using a newer email since what I may have sent you before, but if you're signed in to the Google group thing, you should be able to track me down. Or send a PM.
Title: Photopic negative response reflects severity of ocular circulatory damage after central retinal artery occlusion.
Source: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde (Ophthalmologica) 2009; 223(6): 362-9
Additional Info: Switzerland
Standard No: ISSN: 0030-3755 (Print); 1423-0267 (Electronic); NLM Unique Journal Identifier: 0054655
Language: English
Abstract: PURPOSE: To determine the relationship of the photopic negative response (PhNR) of the photopic electroretinogram (ERG) with the degree of circulatory disturbances in eyes following central retinal artery occlusion (CRAO). METHODS: The circulatory disturbance was graded as mild (group 1) when the arm-to-retina transmission time was <30 s, moderate (group 2) when the time was >30 s and severe (group 3) when concurrent choroidal circulatory damage was found. For statistical analysis, groups 1, 2 and 3 were scored as 1, 2 and 3, respectively. Photopic ERGs were elicited by either short-flash (SF) or long-flash (LF) stimuli. RESULTS: Both the SF and LF PhNR were significantly reduced in groups 2 and 3. The PhNR amplitude was negatively correlated with the severity of the ocular circulatory disturbances (p = 0.0498, rho = -0.507 for SF PhNR; p = 0.0050, rho = -0.750 for LF PhNR). CONCLUSION: The amplitude of the PhNR became more reduced as the severity of the circulatory disturbances increased in eyes with CRAO.
Copyright 2009 S. Karger AG, Basel.
Title: Retinal artery occlusion: associated systemic and ophthalmic abnormalities.
Source: Ophthalmology (Ophthalmology) 2009 Oct; 116(10): 1928-36
Additional Info: United States
Standard No: ISSN: 0161-6420 (Print); 1549-4713 (Electronic); NLM Unique Journal Identifier: 7802443
Language: English
Abstract: OBJECTIVE: To investigate systematically the various associated systemic and ophthalmic abnormalities in different types of retinal artery occlusion (RAO). DESIGN: Cohort study. PARTICIPANTS: We included 439 consecutive untreated patients (499 eyes) with RAO first seen in our clinic from 1973 to 2000. METHODS: At first visit, all patients underwent detailed ophthalmic and medical history, and comprehensive ophthalmic evaluation. Visual evaluation was done by recording visual acuity, using the Snellen visual acuity chart, and visual fields with a Goldmann perimeter. Initially they also had carotid Doppler/angiography and echocardiography. The same ophthalmic evaluation was performed at each follow-up visit. MAIN OUTCOME MEASURES: Demographic features, associated systemic and ophthalmic abnormalities, and sources of emboli in various types of RAO. RESULTS: We classified RAO into central (CRAO) and branch (BRAO) artery occlusion. In both nonarteritic (NA) CRAO and BRAO, the prevalence of diabetes mellitus, arterial hypertension, ischemic heart disease, and cerebrovascular accidents were significantly higher compared with the prevalence of these conditions in the matched US population (all P<0.0001). Smoking prevalence, compared with the US population, was significantly higher for males (P = 0.001) with NA-CRAO and for women with BRAO (P = 0.02). Ipsilateral internal carotid artery had > or =50% stenosis in 31% of NA-CRAO patients and 30% of BRAO, and plaques in 71% of NA-CRAO and 66% of BRAO. An abnormal echocardiogram with an embolic source was seen in 52% of NA-CRAO and 42% of BRAO. Neovascular glaucoma developed in only 2.5% of NA-CRAO eyes. CONCLUSIONS: This study showed that, in CRAO as well as BRAO, the prevalence of various cardiovascular diseases and smoking was significantly higher compared with the prevalence of these conditions in the matched US population. Embolism is the most common cause of CRAO and BRAO; plaque in the carotid artery is usually the source of embolism and less commonly the aortic and/or mitral valve. The presence of plaques in the carotid artery is generally of much greater importance than the degree of stenosis in the artery. Contrary to the prevalent misconception, we found no cause-and-effect relationship between CRAO and neovascular glaucoma.
MESH Subject(s) below:
Descriptor: (Major): Diabetes Complications
Smoking
(Minor): Aged
Cohort Studies
Coronary Angiography
Echocardiography, Doppler
Female
Follow-Up Studies
Glaucoma, Neovascular -- complications
Humans
Hypertension -- complications
Male
Middle Aged
Myocardial Ischemia -- complications
Prospective Studies
Retinal Artery Occlusion -- complications
Visual Acuity
Visual Fields
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sj
